Will a mutation on the SENSE strand changes anything? During replication, it is only the ANTI-sense strand is transcribed.
4 years ago
Answered By Dr. Amandeep T
A mutation in the "sense" strand will affect the next generation if its in the "sense" strand of the DNA of germ cells, given the situation that the mutation does not get repaired by the DNA repair mechanisms of that cell.
4 years ago
Answered By Leora C
To add to Dr. Amandeep’s answer, yes, it could change things. It would be dependent upon which cells the mutation occurred in. If the mutation occurred in a germ cell, and wasn’t repaired, a mutation would show up in both the sense and anti-sense strands as that DNA is replicated due to the strands needing to form chemical bonds with one another. Even though the anti-sense strand is being transcribed, it must match up with the nucleotides of the sense strand. What would also matter would be if the DNA in question is in a coding region of the DNA (exon).
4 years ago
Answered By Manasa R
In basic transcription, not ocnsidering anythign else, the mutation to the sense strand wont change anything, a mutation to the anti-sense strand definetly would change it because it would affect the amino acid that would pair with it (codon).
4 years ago
Answered By manjula b
LET US BEGIN WITH AN EXAMPLE OF MUTATION IN SENSE STRAND OF DNA , IF A SPELLING ERROR OCCURS (GCA –GCT) IN WHICH AN “A” IS REPLACED BY AT IN THS SENSE STRAND , CAUSING COMPLEMETERY CHANGES IN THE ANTISENSE DNA STRAND ALSO.( CGT –CGA)
DURING TRANSCRIPTION m RNA CHANGES FROM GCA TO GCU.
BUT NO CHANCES OCCUR IN THE AMINO ACID BECAUSE OF THE INHERENT REDUNDANCY IN DNA CODE.
SO , ITS ALL DEPEND UPON THE TYPE OF CELL WHERE IN THE MUTATION TAKES PLACE : SOMATIC OR GERM CELL .
MOST SOMATIC CELL MUTATION HAVE NO PRACTICLE IMPACT ON THE ORGANISM.
IF MUTATION TAKES PLACE IN GERM CELL THAT IS FERTILIZED , THE MUTATION IS PRESENT IN ALL THE CELLS OF THE OFFSPRING AND WELL PASSED ON TO THE NEXT GENERATION.
4 years ago
Answered By manjula b
LET US BEGIN WITH AN EXAMPLE OF MUTATION IN SENSE STRAND OF DNA , IF A SPELLING ERROR OCCURS (GCA –GCT) IN WHICH AN “A” IS REPLACED BY "T" IN THS SENSE STRAND , CAUSING COMPLEMETERY CHANGES IN THE ANTISENSE DNA STRAND ALSO.( CGT –CGA)
DURING TRANSCRIPTION m RNA CHANGES FROM GCA TO GCU.
BUT NO CHANCES OCCUR IN THE AMINO ACID BECAUSE OF THE INHERENT REDUNDANCY IN DNA CODE.
SO , ITS ALL DEPEND UPON THE TYPE OF CELL WHERE IN THE MUTATION TAKES PLACE : SOMATIC OR GERM CELL .
MOST SOMATIC CELL MUTATION HAVE NO PRACTICLE IMPACT ON THE ORGANISM.
IF MUTATION TAKES PLACE IN GERM CELL THAT IS FERTILIZED , THE MUTATION IS PRESENT IN ALL THE CELLS OF THE OFFSPRING AND WELL PASSED ON TO THE NEXT GENERATION.
4 years ago
Answered By Dr. Amandeep T
A mutation in the "sense" strand will affect the next generation if its in the "sense" strand of the DNA of germ cells, given the situation that the mutation does not get repaired by the DNA repair mechanisms of that cell.
4 years ago
Answered By Leora C
To add to Dr. Amandeep’s answer, yes, it could change things. It would be dependent upon which cells the mutation occurred in. If the mutation occurred in a germ cell, and wasn’t repaired, a mutation would show up in both the sense and anti-sense strands as that DNA is replicated due to the strands needing to form chemical bonds with one another. Even though the anti-sense strand is being transcribed, it must match up with the nucleotides of the sense strand. What would also matter would be if the DNA in question is in a coding region of the DNA (exon).
4 years ago
Answered By Manasa R
In basic transcription, not ocnsidering anythign else, the mutation to the sense strand wont change anything, a mutation to the anti-sense strand definetly would change it because it would affect the amino acid that would pair with it (codon).
4 years ago
Answered By manjula b
LET US BEGIN WITH AN EXAMPLE OF MUTATION IN SENSE STRAND OF DNA , IF A SPELLING ERROR OCCURS (GCA –GCT) IN WHICH AN “A” IS REPLACED BY AT IN THS SENSE STRAND , CAUSING COMPLEMETERY CHANGES IN THE ANTISENSE DNA STRAND ALSO.( CGT –CGA)
DURING TRANSCRIPTION m RNA CHANGES FROM GCA TO GCU.
BUT NO CHANCES OCCUR IN THE AMINO ACID BECAUSE OF THE INHERENT REDUNDANCY IN DNA CODE.
SO , ITS ALL DEPEND UPON THE TYPE OF CELL WHERE IN THE MUTATION TAKES PLACE : SOMATIC OR GERM CELL .
MOST SOMATIC CELL MUTATION HAVE NO PRACTICLE IMPACT ON THE ORGANISM.
IF MUTATION TAKES PLACE IN GERM CELL THAT IS FERTILIZED , THE MUTATION IS PRESENT IN ALL THE CELLS OF THE OFFSPRING AND WELL PASSED ON TO THE NEXT GENERATION.
4 years ago
Answered By manjula b
LET US BEGIN WITH AN EXAMPLE OF MUTATION IN SENSE STRAND OF DNA , IF A SPELLING ERROR OCCURS (GCA –GCT) IN WHICH AN “A” IS REPLACED BY "T" IN THS SENSE STRAND , CAUSING COMPLEMETERY CHANGES IN THE ANTISENSE DNA STRAND ALSO.( CGT –CGA)
DURING TRANSCRIPTION m RNA CHANGES FROM GCA TO GCU.
BUT NO CHANCES OCCUR IN THE AMINO ACID BECAUSE OF THE INHERENT REDUNDANCY IN DNA CODE.
SO , ITS ALL DEPEND UPON THE TYPE OF CELL WHERE IN THE MUTATION TAKES PLACE : SOMATIC OR GERM CELL .
MOST SOMATIC CELL MUTATION HAVE NO PRACTICLE IMPACT ON THE ORGANISM.
IF MUTATION TAKES PLACE IN GERM CELL THAT IS FERTILIZED , THE MUTATION IS PRESENT IN ALL THE CELLS OF THE OFFSPRING AND WELL PASSED ON TO THE NEXT GENERATION.